Research Profile for Zarkadis K Ioannis


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General
Zarkadis K. Ioannis
Department of Medicine,Department of Medicine
Research Activity
Molecular evolution, innate immunity, complement system,human diseases, bioinformatics, raibow trout, chicken,
Evolution of immune system.
Molecular studies of complement system in teleost and birds.
Extension of immune diversity in rainbow trout.
The lytic pathway of complement system in chicken.
Complement system and human diseases.
Studies of regulatory complement genes fH and fB/C2 in AMD (Age related macular degeneration).
Studies of complement system in immunodeficiency syndromes
Research Infrastructure
Ioannis K Zarkadis Associate Professor
Maria Chodrou PhD student
Anastasios Papanastasiou PhD student
Dimitra Marioli Master student
Angeliki Mikrou Master student
Sylvia Mylona Master student
cDNA , genomic libraries (synthesis, screening)
DNA cloning
DNA sequencing
Gene expression mRNA level (northern, in situ, RT-PCR)
Gene expression protein level (ELISA, immunocytochemistry)
Modeling, phylogenetic analysis
Mutations, SNPs identification

Research Activities
Studies of complement evolution in teleost
Studies of complement evolution in birds
Complement system and human diseases
Chondrou MP, Mastellos D, Zarkadis IK.( 2006). cDNA cloning and phylogenetic analysis of the sixth complement component in rainbow trout. Mol Immunol. 43(8):1080-7.
Papanastasiou AD and Zarkadis IK. (2006).The gamma subunit of the eighth complement component (C8) in rainbow trout. Dev Comp Immunol. 30: 485-491
Papanastasiou AD and Zarkadis IK (2006). Cloning and phylogenetic analysis of the alpha subunit of the eighth complement component (C8) in rainbow trout. Molecular Immunology 43(14):2188-94
Papanastasiou AD, Georgaka E, and Zarkadis IK (2006). Cloning of a CD59-like gene in rainbow trout. Expression and phylogenetic analysis of two isoforms. Molecular Immunology. 44(6):1300-6.
Georgaka Eleftheria, Nastopoulos Vassilios, Eleftheriou Sofia and I. K Zarkadis (2007). toxin-like gene in rainbow trout: cloning, expression, and gene organization. Toxicon 49 (7): 1002-1009.
Marioli DJ, Zarkadis IK. (2008). The vitronectin gene in rainbow trout: Cloning, expression and phylogenetic analysis. Fish Shellfish Immunology. 24(1):18-25
Londou A, Mikrou A, Zarkadis IK (2008).Cloning and characterization of two clusterin isoforms in rainbow trout.Mol Immunol. 45(2):470-8.
University of Pennsylvania, School of Medicine (Prof. John D. Lambris)
Institute Demokritos (Dr Dimitris Mastellos)
Department of Pharmacy, Univ. of Patras (Assist. Prof. Georgios Spyroulias)
Department of Chemistry, Univ. of Patras (Assoc. Prof. Vassilios Nastopoulos)
Hospital METAXA (Dr Georgios Christakis)
Additional Information