Research Profile for Kardamakis Dimitrios

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Department of Radiation Oncology
Department of Medicine,Department of Clinical Radiology
Research Activity
radiation oncology, biphosphonates, geriatrics, radiobiology, angiogenesis, health economics, history of medicine,
My main field of clinical research focuses on the treatment of rectal, brain and prostate cancer. I am also applying stereotactic radiotherapy to patients with brain tumours. The recent years I am investigating the synergistic activities of biphosphonates and radiotherapy. In parallel to these, I am studying aspects of health economics, geriatric medicine and history of medicine. At a basic research level, I am involved in studying the effects of ionizing radiation on angiogenesis and also the effects of low dose ionizing radiation to normal and cancerous cells.
Research Infrastructure
Dimitris Kardamakis MD, PhD, Associate Professor
Vassilios Vassiliou MD, PhD, Lecturer
Efstathia Giannopoulou PhD, Post-Doc
Despoina Spyropoulou MD, PhD student
Linear accelerators
Stereotactic Radiotherapy Unit
Research Lab for cell cultures, molecular biology
Research Activities
Radiotherapy in elderly breast cancer patients
Biphosphonates in the treatment of bone metastases
Sexuality in cancer patients
Effects of low dose ionizing radiation on human cells
Kardamakis D et al.Low-dose total-body irradiation in the management of refractory rheumatoid arthritis.Br J Radiol. 1987, 60(711):297-299.
Kardamakis D et al. Recombinant human interferon alpha-2b enhances the radiosensitivity of small cell lung cancer in vitro. Anticancer Res. 1989, 9(4):1041-1044.
Dahl O, Kardamakis D et al.Current status of conformal radiotherapy.Acta Oncol. 1996,35 Suppl 8:41-57.
Hatjikondi O, Ravazoula P, Kardamakis D et al.In vivo experimental evidence that the nitric oxide pathway is involved in the X-ray-induced antiangiogenicity.Br J Cancer. 1996,74(12):1916-1923.
C. Kappas, K. Theodorou, D. Kardamakis et al. Design, Construction and Installation of a New Stereotactic System for Single Dose and Fractionated Radiotherapy.Physica Medica, 1997, Vol. XIII(3),123-127.
Gueorguieva K, Bliznakov J, Kolitsi Z, Kardamakis D et al.An integrated system for the production of field shaping devices in radiotherapy.Med Eng Phys. 1999, 21(1):45-51.
Skarlos DV, Samantas E, Briassoulis E, Panoussaki E, Pavlidis N, Kalofonos HP, Kardamakis D, et al. Randomized comparison of early versus late hyperfractionated thoracic irradiation concurrently with chemotherapy in limited disease small-cell lung cancer: a randomized phase II study of the Hellenic Cooperative Oncology Group (HeCOG). Ann Oncol. 2001, 12(9):1231-1238.
Giannopoulou E, Katsoris P, Hatziapostolou M, Kardamakis D et al.X-rays modulate extracellular matrix in vivo. Int J Cancer. 2001, 94(5):690-698.
Scopa CD, Vagianos C, Kardamakis D et al.bcl-2/bax ratio as a predictive marker for therapeutic response to radiotherapy in patients with rectal cancer.Appl Immunohistochem Mol Morphol. 2001, 9(4):329-334.
Iconomou G, Viha A, Kalofonos HP, Kardamakis D. Impact of cancer on primary caregivers of patients receiving radiation therapy.Acta Oncol. 2001;40(6):766-771.
Giannopoulou E, Katsoris P, Kardamakis D et al.Amifostine inhibits angiogenesis in vivo.J Pharmacol Exp Ther. 2003, 304(2):729-737.
Van Der Giessen PH, Alert J, Badri C, Bistrovic M, Deshpande D, Kardamakis D et al.Multinational assessment of some operational costs of teletherapy. Radiother Oncol. 2004, 71(3):347-355.
Giannopoulou E., Ravazoula P., Kalofonos H. and Kardamakis D. Expression of HIF-1α and iNOS in astrocytic gliomas: A clinicopathological study. Ιn Vivo 20(3), 421-425, 2006
Vassiliou V, Kalogeropoulou C, Christopoulos C, Solomou E, Leotsinides M, Kardamakis D.Combination ibandronate and radiotherapy for the treatment of bone metastases: clinical evaluation and radiologic assessment.Int J Radiat Oncol Biol Phys. 2007, 67(1):264-272.
Zampakis P, Karnabatidis D, Kalogeropoulou C, Kardamakis DM et al.External beam irradiation and restenosis following femoral stenting: long-term results of a prospective randomized study.Cardiovasc Intervent Radiol. 2007, 30(3):362-369.
Matsouka P, Mylonas P, Papandoniou E, Dimitropoulou I, Floratou K, Alexandridis T, Kardamakis D.Abdominal radiation initiates apoptotic mechanism in rat femur bone marrow cells in vivo that is reversed by IGF-1 administration.J Radiat Res (Tokyo). 2008, 49(1):41-47.
Kalofonos HP, Bamias A, Koutras A, Papakostas P, Basdanis G, Samantas E, Karina M, Misailidou D, Pisanidis N, Pentheroudakis G, Economopoulos T, Papadimitriou C, Skarlos DV, Pectasides D, Stavropoulos M, Bafaloukos D, Kardamakis et al.A randomised phase III trial of adjuvant radio-chemotherapy comparing Irinotecan, 5FU and Leucovorin to 5FU and Leucovorin in patients with rectal cancer: a Hellenic Cooperative Oncology Group Study.Eur J Cancer. 2008, 44(12):1693-1700.
Karolinska Radiummhemet
European Society for the Therapeutic Radiology and Oncology
Hellenic Cooperative Oncology Group
International Society of Geriatric Oncology
Additional Information