Research Profile for Kalofonos Haralambos


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General
Kardamakis Dimitris
Department of Medicine
Research Activity
 
Studies in recent years have demonstrated a radiobiologic phenomenon termed “bystander or abscopal effect”. This phenomenon describes biologic effects (i.e. cell death) occurring in non-irradiated cells but originating from irradiated cells. Our research group studies the mechanisms via which the unirradiated cells react to signals produced by irradiated cells. This effect plays an important role in radiobiology and radiotherapy. The abscopal effect is potentially important for tumour control and is mediated through cytokines and/or the immune system, mainly cell-mediated immunity. It results from loss of growth stimulatory and/or immunosuppressive factors from the tumour. Although the abscopal effect has been described in various malignancies, it is a rarely recognized clinical event. A radiotherapist has to concern the role of this phenomenon for the protection of neighbouring healthy tissue when a tumour is irradiated. New approaches may be developed to improve the efficiency of radiation treatment if the mechanisms underpinning these responses can be controlled
Research Infrastructure
Dimitris Kardamakis MD, PhD, Ass. Professor
Haralabos Kalofonos MD, PhD, Ass. Professor
Efstathia Giannopoulou, Post-Doc personnel
Maria Martinou MD, PhD student
 
Research Activities
 
Giannopoulou E., Ravazoula P., Kalofonos H. and Kardamakis D. Expression of HIF-1α and iNOS in astrocytic gliomas: A clinicopathological study. Ιn Vivo 20(3), 421-5, 2006
 
Additional Information