Research Profile for Papachatzopoulou Adamadia


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General
Laboratory of General Biology
Department of Medicine
Research Activity
beta-thalassemia,intermedia,expression-beta-globin cluster,polymorfisms,diseases,HbF-expression,real-timePCR, microarrays
1. Study of expression of human beta-globin gene cluster
2. Study of beta-thalassemia intermedia genotypes
3. Detection of mutations and polymorphisms associated with human diseases
Research Infrastructure
Adamantia Papachatzopoulou, Assistant Professor of Molecular Biology and Molecular Genetics
Real-time PCR, microarrays, confocal microscope, cell cultures
Research Activities
PHARMACOGENOMIC ANALYSIS OF β-THALASSEMIA/SICKLE CELL PATIENTS UNDER HYDROXYUREA TREATMENT: IMPLICATIONS FOR DISEASE THERAPEUTICS
1.Sgourou A., Routledge S., Antoniou M., Papachatzopoulou A., Psiouri L., Athanassiadou A. “Thalassaemia mutations within the 5’UTR of the human beta-globin gene disrupt transcription”. Br.J.Haematol. 124(6):828-35, 2004

2.Papachatzopoulou A., Kourakli A., Makropoulou P., Kakagianne T., Sgourou A., Papadakis M., Athanassiadou A. “ Genotypic heterogeneity and correlation to intergenic haplotype within high HbF β-thalassemia intermedia”. Eur. J. Haematol. 76: 322 –330, 2006

3. Georgopoulos NA, Koika V, Galli-Tsinopoulou A, Spiliotis BE, Adonakis G, Keramida MK, Sgourou A, Koufogiannis KD, Papachatzopoulou A, Papavassiliou AG, Kourounis G, Vagenakis GA. «Renal dysgenesis and KAL1 gene defects in patients with sporadic Kallmann syndrome». Fertil Steril. 2007 Nov;88(5):1311-7

4. Voutsinas G., Stavrou E. , Karousos G., Dasula A., Papachatzopoulou A, Syrrou M., Verkerk A., Patrinos G., Stöger R., Athanassiadou A. «Allelic imbalance of expression and epigenetic regulation within the alphasynuclein wt and A53T gene alleles in Parkinson’s Disease». Hum Mutat. 2010 Jun;31(6):685-91

5. Giardine B, Borg J, Higgs DR, Peterson KR, Philipsen S, Maglott D, Singleton BK, Anstee DJ, Basak AN, Clark B, Costa FC, Faustino P, Fedosyuk H, Felice AE, Francina A, Galanello R, Gallivan MV, Georgitsi M, Gibbons RJ, Giordano PC, Harteveld CL, Hoyer JD, Jarvis M, Joly P, Kanavakis E, Kollia
P, Menzel S, Miller W, Moradkhani K, Old J, Papachatzopoulou A,
Papadakis MN, Papadopoulos P, Pavlovic S, Perseu L, Radmilovic M, Riemer C, Satta S, Schrijver I, Stojiljkovic M, Thein SL, Traeger-Synodinos J, Tully R, Wada T, Waye JS, Wiemann C, Zukic B, Chui DH, Wajcman H, Hardison RC, Patrinos GP. «Systematic documentation and analysis of human genetic variation in hemoglobinopathies using the microattribution approach». Nat Genet 2011 Mar 20; 43(4):295-301
George P. Patrinos Ph.D
Erasmus University
Faculty of Medicine and Health Sciences
Department of Cell Biology and Genetics
Dr. Molewaterplain 50
3015 GE Rotterdam
Holland
Additional Information