Research Profile for Taraviras Stavros


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General
Stavros Taraviras
Department of Medicine
Research Activity
Systems biology, Neuroscience, Stem cell and regenerative medicine, Mouse models, Human disease
Our research is focused on understanding the mechanisms that are involved in the coordination of proliferation and differentiation in stem/progenitor cells of the nervous and immune system. We are aiming to identify molecular cues participating in the coordination of cell cycle regulation, fate specification and differentiation programs. Moreover, we are exploiting the mechanisms that aberrant regulation of proliferation and differentiation can lead to tumorigenesis and neurodegeneration.
Research Infrastructure
Stavros Taraviras Associate Professor,
4 PhD students,
1 Master Diploma students
Confocal Microscope (Leica SP5, equiped for live-cell imaging, time-lapse, FRAP, FRET, FLIP etc)
Wide-field Epifluorescence Microscope (Nikon TE2000U)
Microarray Scanner (Proscan Array, PerkinElmer)
Microarray Hybridizer (HybArray 12, PerkinElmer)
Bioanalyser (Agilent)
LightCycler (Roche)
All required equipment for cell culture work, molecular biology, genetic engineering, protein biochemistry etc
Research Activities
 
• Karamitros D, Kotantaki P, Lygerou Z, Kioussis D, Taraviras S. (2011) T cell proliferation and homeostasis: an emerging role for the cell cycle inhibitor geminin. Crit Rev Immunol. 31(3):209-31.

• Spella M, Kyrousi C, Kritikou E, Guillemot F, Pachnis V, Kioussis D, Lygerou Z, Taraviras S. Geminin regulates self renewal and differentiation decisions in cortical pro-genitor cells during embryogenesis. (2011). Stem Cells, Aug;29(8):1269-82.

• Roukos V, Kinkhabwala A, Colombelli J, Kotsantis P, Taraviras S, Nishitani H, Stelzer E, Bastiaens P, Lygerou Z. (2011) Dynamic recruitment of licensing factor Cdt1 to sites of DNA damage. J Cell Sci. Feb 1;124(Pt 3):422-34.

• Karamitros D, Kotantaki P, Lygerou Z, Veiga-Fernandes H, Pachnis V, Kioussis D, and Taraviras S. (2010). Life without Geminin.Cell Cycle. Aug 15;9(16):3181-5.

• Mantamadiotis T and Taraviras S. (2010) Self-renewal mechanisms in neural cancer stem cells. Frontiers in Bioscience. Jan 1;16:598-607.

• Karamitros D, Kotantaki P, Lygerou Z, Veiga-Fernandes H, Pachnis V, Kioussis D, and Taraviras S. (2010). Differential Geminin requirement for proliferation of thymocytes and mature T cells. Journal of Immunology. Volume 184, 5. 2432-2441.

• De Marco V, Gillespie PJ, Li A, Karantzelis N, Christodoulou E, Klompmaker R, van Gerwen S, Fish A, Petoukhov MV, Iliou MS, Lygerou Z, Medema RH, Blow JJ, Svergun DI, Taraviras S, Perrakis A. (2009) The quaternary structure of the human Cdt1-Geminin complex regulates DNA replication licensing. Proc. Natl. Acad. Sci. U.S.A.. Nov 24;106(47):19807-12.

• Petropoulou, C., Kotantaki, P., Karamitros, D., Taraviras, S. (2008) Cdt1 and Geminin in cancer: Markers or triggers of malignant transformation? Frontiers in Bioscience 13, 4485-4494.

• Liontos M, Koutsami M, Sideridou M, Evangelou K, Kletsas D, Levy B, Kotsinas A, Nahum O, Zoumpourlis V, Kouloukoussa M, Lygerou Z, Taraviras S, Kittas C, Bartkova J, Papavassiliou AG, Bartek J, Halazonetis TD, Gorgoulis VG. (2007) Deregulated overexpression of hCdt1 and hCdc6 promotes malignant behavior. Cancer Res. Nov 15;67(22):10899-909.

• Spella M, Britz O, Kotantaki P, Lygerou Z, Nishitani H, Ramsay RG, Flordellis C, Guillemot F, Mantamadiotis T, Taraviras S. (2007). Licensing regulators Geminin and Cdt1 identify progenitor cells of the mouse CNS in a specific phase of the cell cycle. Neuroscience. 147:373-387.

• V. Roukos, M. S. Iliou, H. Nishitani, M. Gentzel, M. Wilm, S. Taraviras and Z. Lygerou (2007). Geminin cleavage during apoptosis by caspase-3 alters its binding ability to the SWI/SNF subunit Brahma. J. Biol. Chem. 282, 13, 9346-9357.

• G. Xouri, A. Squire, M. Dimaki, B. Geverts, P. J. Verveer, S. Taraviras, H. Nishitani, A. B. Houtsmuller, P. I. H. Bastiaens, Z. Lygerou (2007). Dynamic chromatin association of Cdt1 throughout G1 leads to Geminin recruitment onto chromatin. EMBO J. 26, 1303–1314.

• Xouri Z., Lygerou Z., Nishitani H., Pachnis V., Nurse P., Taraviras S. (2004). The licensing factor cdt1 and its inhibitor Geminin are both down-regulated upon cell cycle exit and over-expressed in cancer cells. Eur J Biochem. Aug;271(16):3368-78.

• Taraviras, S., Marcos-Gutierrez, C., Durbec, P., Jani, H., Grigoriou, M., Sukumaran, M., Wang, L., Hynes, M., Raisman, G. and Pachnis V. (1999). Signalling by the RET receptor tyrosine kinase and its role in the development of the mammalian enteric nervous system. Development. 126, 2785-2797.

• Taraviras, S. and Pachnis, V. (1999). Development of the mammalian enteric nervous system. Current Opinion in Genetics and Development. 9, 321-327.
MRC/National Institute for Medical Research, UK
Netherland Cancer Institute (NKI), NL
University of Athens, Medical School, Department of Histology
Medical School, Imperial College, UK
Additional Information