Research Profile for Mouzaki Athanasia


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General
Immunohematology Laboratory
Faculty of Medicine, Department of Internal Medicine, Division of Hematology, Laboratory of Immunohematology
Research Activity
Immunohematology, cellular and molecular immunology, transfusion medicine, autoimmune diseases, HIV, transplantation, hematological malignancies, cytokines, T cells, tolerance
See CV
Research Infrastructure
A. Mouzaki-head of the lab

Core research group:
1 post-doctoral fellow,
6 post-graduate students
3 diploma students



Complete facilities for cell culture (laminar flow cabinets, incubators, microscopes, centrifuges including ultracentrifuge, liquid N2 containers), equipment for FACS analysis and cell sorting, PCR and real time PCR instruments, DNA sequencing instrument, ELISA and bead (FACSarray) readers, and all common life lab instruments (electropheresis apparatus for DNA, RNA and protein analysis, autoradiography equipment, sonicator, freezers, deep freezers, Ph meters, vortexers, CO2 incubators, spectrophotometers, etc.)
Research Activities
IL-2 & HIV-1:
We are studying the transcriptional regulation of the IL-2 gene and the virus HIV-1 by common trans-active factors in naive, memory and regulatory T helper lymphocytes.
Hypersensitivity: Autoimmunity & Transplantation:
(1) Identification of putative errors in the transcriptional regulation of cytokine genes in T-cells from patients suffering from autoimmune diseases.
(2) Use of therapeutic peptides in immunotherapy of autoimmune diseases, targeting effector T-cells and T regulatory cells.
(3) Role of leptin and its receptor in autoimmune diseases.
(4) Effect of immunosuppressive drugs on T regulatory cells of transplant recipients.
(5) Use of therapeutic peptides in transplantation.
Neoplasias:
(1) Defining drug targets in multiple myeloma.
(2) Role of leptin and its receptor in leukemias and multiple myeloma.
(3) Use of therapeutic peptides in immunotherapy of cancer.
(4) Role of IL-2 transcriptional silencers in the pathogenesis of cancer.
Transfusion medicine
(1) Effect of molecular screening for viruses in blood donations.
(2) Effect of blood transfusion on T regulatory cell populations of transfused patients undergoing orthopedic surgery.

Mouzaki et al., 1987, Eur. J. Immunol., 17:335-341.
Di Stefano et al., 1988, J. Exp. Med., 167:1981-1986.
Mouzaki et al., 1991, EMBO J., 10(6):1399-1406.
Hentsch et al., 1992, Nucleic Acids Res., 20(11):2657-2665.
Mouzaki et al., 1993, Eur. J. Immunol., 23:1469-1474.
Mouzaki A & Rungger D, 1994, Blood, 84(8):2612-2621.
Mouzaki et al., 1995. Eur. J. Immunol., 25:2177-2182.
Mouzaki et al., 1995, Br. J. Haematol., 91:345-349.
Mouzaki et al., 2000, Mol. Med., 6(5):377-390.
Mouzaki et al., 2002, Blood, 100(5):1774-1779.
Panitsas et al., 2004, Blood, 103(7):2645-2647.
Argyropoulos et al., 2004, Genes Immun., 5(1):16-25.
Chatzantoni et al., 2004, J. Autoimmun., 23(2):169-177.
Sgourou et al., 2008, Transfus. Med., 18(2):104-11.
Deraos et al, 2008, J. Med. Chem., 51(24):7834-7842.
Mouzaki et al., 2009, Cytokine, 48:203-211.
Fourtounas et al., 2010, Am. J. Nephrol., 32(1):1-9.
Varvarigou et al., 2012, Cytokine, 58(3):355-360.
Mouzaki et al., 2012, PLoS One, 7(7):e40830

Department of Hematology-University of Athens Medical School.
Center of Basic Research II-Biomedical Research Foundation Academy of Athens.
Immunology and Vaccine Laboratory, 
Burnet 
Centre for Immunology, Melbourne, Victoria, Australia.

Additional Information