Research Profile for Drainas Dionysios


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General
Drainas D
Department of Medicine
Research Activity
RNase P, M1 RNA, ribozymes, tRNA, antibiotics, macrolides, retinoids
•Studies on the structure and function of RNase P enzymes
•RNase P as a target for the development of new drugs.
•RNase P in gene therapy
•Mitochondrial tRNA Mutations
Research Infrastructure
Dionysios Drainas Professor
Anastassios Vourekas postdoctoral fellow
Vassiliki Stamatopoulou PhD student
Chtisavgi Toumpeki PhD Student
HPLC
Ultracentrifuge
β-Scintillation counter
UV-Vis Spectrophotometer
PhosphoImager
DNA microarrays
PCR
Research Activities
•European Social Fund (ESF), Operational Program for Educational and Vocational Training II (EPEAEK II), HERAKLITOS 2003. Clone and characterization of genes that code protein subunits of the ribonucleoprotein complex of ribonuclease P from the slime mold Dictyostelium discoideum – a key enzyme in tRNA biogenesis.
•General Secretariat of Research and Technology GR, Joint Research and Technology Programme, Greece-Spain, 2005 RNase P as a target for novel inhibitors. Differences in inhibitor sensitivity of bacterial, organellar and eukaryotic RNase P enzymes.
1.Kalavrizioti D, Vourekas A, Stamatopoulou V, Toumpeki C, Giannouli S, Stathopoulos C, and Drainas D. (2006) RNA-mediated therapeutics: from gene inactivation to clinical application. Current Topics in Med. Chem. 6, 1737-1758.
2.Vourekas A, Kalavrizioti D, Zarkadis IK, Spyroulias GA, Stathopoulos C, and Drainas D. (2007). Identification of a gene that encodes a 40.7 kDa protein associated with Dictyostelium discoideum ribonuclease P holoenzyme. Biochimie, 89, 301-310.
3.Kalavrizioti D, Vourekas A, and Drainas D. (2007) DRpp20 and DRpp40, two protein subunits of ribonuclease P from Dictyostelium discoideum. Gene 400, 52-59.
4.Toumpeki C, Vourekas A, Kalavrizioti D, Stamatopoulou V, and Drainas.D. (2008) Activation of bacterial Ribonuclease P by macrolides. Biochemistry 47(13), 4112-4118.
5.Vourekas A, Stamatopoulou V, Toumpeki C, Tsitlaidou M, and Drainas D. (2008) Insights into functional modulation of catalytic RNA activity. IUBMB Life 60(10), 669-83
Professor Agustin Vioque, Instituto de Bioquímica Vegetal y Fotosíntesis, Universidad de Sevilla-C.S.I.C, Spain
Additional Information