Research Profile for Kalpaxis L. Dimitrios

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Kalpaxis D.
Research Activity
protein synthesis, ribosome, antibiotics, anticancer drugs, polyamines, polyamine analogs, biomarkers
1. Structure and function of ribosomes
2. Mechanism of action of antibiotics which inhibit protein synthesis-Development of new drugs
3. Role of polyamines in protein synthesis-Synthesis of polyamine analogs and their use as anticancer drugs
4. Protein synthesis in invertebrates as a biomarker of marine pollution-Correlations with other standard biomarkers
Research Infrastructure
Dimitrios L. Kalpaxis - Professor
George Dinos - Associate Professor
Ekaterini Kouvela, PhD student
Sofia Pytharopoulou, PhD student
1. Ultra-centrifuge
2. Scintillation counter
3. UV-VIS spectrophotometer
4. HPLC analyzer
5. PhosphoImager
6. DNA microarrays
Research Activities
Recent research projects:
1.“Structural and functional studies on the effect of polyamines on the catalytic ribosomal subunit of Escherichia coli”, European Social Fund (ESF), Operational Program for Educational and Vocational Training II (EPEAK II), Program IRAKLEITOS, Ministry of Development, 2003
2.“Influence of polyamines on the action of antibiotics of macrolide family”, Programme «Κ. ΚΑRATHEODORI», University of Patras, 2003
3."Monitoring of the environmental quality in Greek seas", Ministry of the Environment, Physical Planning and Public Works, 2004
4.“Monitoring of biological effects of pollution along the Patraikos Gulf of Greece”, MEL-2322-2918-2664 BL2202 United Nations, MED. POL. Research Programme, 2006-2008
1.Dinos, G., Wilson, D., Teraoka, Y., Szaflarski, W., Fucini, P., Kalpaxis, D. L. and Nierhaus, K. (2003). Dissecting the inhibition mechanisms of edeine and pactamycin: Antagonistic interplay on the ribosome between these translational inhibitors. Μοl. Cell, 13, 113-124.

2. M.A. Xaplanteri, G. Papadopoulos, F. Leontiadou, T. Choli-Papadopoulou and D. L. Kalpaxis* (2007). The contribution of the zing-finger motif to the function of Thermus thermophilus ribosomal protein S14. J. Mol. Biol., 369, 489-497

3. E. C. Kouvela, G. V. Gerbanas, M. A. Xaplanteri, A. D. Petropoulos, G. P. Dinos and D. L. Kalpaxis* (2007). Changes in the conformation of 5S rRNA cause alterations in principal functions of the ribosomal nanomachine. Nucleic Acids Res., 35, 5108-5119

4. A. D. Petropoulos, E. C. Kouvela, G. P. Dinos and D. L. Kalpaxis* (2008). Step-wise binding of tylosin and erythromycin to Escherichia coli ribosomes, characterized by kinetic and footprinting analysis. J. Biol. Chem., 283, 4756-4765

5. S. Pytharopoulou, E. Sazakli, K. Grintzalis, C. D. Georgiou, M. Leotsinidis, D. L. Kalpaxis* (2008). Translational responses of Mytilus galloprovincialis to environmental pollution: integrating the responses of oxidative stress and other biomarkers into a general stress index. Aquat. Toxicol., 89, 18-27
1. Max-Planck Institute for Molecular Genetics, Berlin, Germany

2. Gene Center and Department of Chemistry and Biochemistry, Ludwig-Maximilians-University of Munich, Germany

3. Institute fur Pharmazeutische Biologie, Johann Wolfgang Goethe-Universitat, Frankfurt am Main, Germany
Additional Information