Research Profile for Kostopoulos George


«Return to previous page
General
Neurophysiology Unit
Department of Medicine,Department nof Physiology
Research Activity
Neuroscience, Neurophysiology, epileptology, sleep, brain rhythms, electroencephalography, computational neuroscience, synaptic transmission, neuronal excitability
Experimental Neurophysiology in vitro (rat brain slices) and in vivo (animal and human electroencephalography and evoked potentials. The experiments are complemented by modeling and signal analysis software development
The studies aim to help understanding of the neuronal mechanisms underlying
1. Synaptic modification underlying learning and memory
2. circuit properties leading to neuronal synchronization and rhythm generation.
3. epileptogenesis
4. Sometosensory processing
5. sleep
Research Infrastructure
George Kostopoulos, Professor of Physiology, Medical School,
Costas Papatheodoropoulos, Assistant Professor of Physiology, Medical School,
Athanasios Koutras, Assistant Professor of Electronics (TEI)
Post doctoral fellows = 2
PhD students = 6
- a human EEG lab
- two electrophysiology set-ups for in vitro work in brain slices
- one electrophysiology set-up for in vivo recordings from the brain of anesthetized animals
- softeware - some home made - for electrophysiological signal analysis.
Research Activities
Zainea O.F., Kostopoulos G.K., Ioannides A.A. Clustering of early cortical responses to median nerve stimulation from average and single trial MEG and EEG signals. Brain Topography 17 (4): 219-236, 2005.
Papatheodoropoulos C, Moshovos C. and Kostopoulos GK , Greater contribution of NMDA receptors in ventral compared to dorsal hippocampal slices in the expression and long-term maintenance of epileptiform activity. Neuroscience, 2005, 135(3): 765-779.
52. Papatheodoropoulos C. and Kostopoulos G. Decreased ability of rat temporal hippocampal CA1 region to produce LTP. Neuroscience Letters, 2000, 279(3): 177-180
53. Ekonomou A, Sperk G, Kostopoulos G and AngelatouF Reduction of a1 adenosine receptors in rat hippocampus after kainic acid–induced limbic seizures. Neuroscience Letters, 2000, 284 (1-2): 49-52.
54. Papatheodoropoulos C. and Kostopoulos G Dorsal-ventral differentiation of short-term synaptic plasticity in rat CA1 hippocampal region. Neuroscience Letters, 2000 286: 57-60.
55. Kostopoulos GK. Spike-and-wave discharges of absence seizures as a transformation of sleep spindles: the continuing development of a hypothesis. Clin Neurophysiol. 2000; 111 Suppl 2:S27-S38.
56. Sargsyan AM, Papatheodoropoulos C, Kostopoulos GK Modeling of evoked field potentials in hippocampal CA1 area describes their dependence on NMDA and GABA receptors. J. Neuroscience Methods, 2001, 104(2), 143-153.
57. Kostopoulos GK Involvement of the thalamocortical system in epileptic loss of consciousness”, 2001, Epilepsia 42 (s3), 13-19.
58. Papatheodoropoulos C and Kostopoulos G, Spontaneous GABA-dependent synchronous periodic activity in adult rat ventral hippocampal slices. Neuroscience Letters 319 (2002) 17–20
59. Ioannides AA, Kostopoulos GK, Laskaris NA, Liu L, Shibata T, Schellens M, Poghosyan V and Khurshudyan A Timing and connectivity in the human somatosensory cortex from single trial mass electrical activity. Human Brain Mapping, 2002;15(4):231-46
60. Papatheodoropoulos C. and Kostopoulos G. Spontaneous low frequency (~ 2-3 Hz) field activity generated in rat ventral hippocampal slices perfused with normal medium. Brain Research Bulletin 2002; 57(2):187-193.
61. Papatheodoropoulos C, Asprodini E, Nikita I, Koutsona C and Kostopoulos G, Weaker synaptic inhibition in CA1 region of ventral compared to dorsal rat hippocampal slices, Brain Research, 2002, 948(1-2):117-21.
62. Grivas I, H. Michaloudi, Ch. Batzios, M. Chiotelli, C. Papatheodoropoulos, G.K. Kostopoulos and G. C. Papadopoulos. Vascular network of the rat hippocampus is not homogeneous along the septotemporal axis, Brain Research, 2003, vol. 971, p. 245-249.
63. Sargsyan AR, Melkonyan A, Papatheodoropoulos C, Mkrtchian HH, Kostopoulos GK, A Model Synapse that Incorporates the Properties of Short- and Long-Term Synaptic Plasticity. Neural Networks 2003; 16(8):1161-77.
64. Badea A., Kostopoulos GK and Ioannides AA Surface Visualization of Electromagnetic Brain Activity. J. Neuroscience Methods, 2003;127(2):137-47.
65. Ioannides AA, Corsi-Cabrera M, Fenwick P, del Rio Portilla Y, Laskaris N, Khurshudyan A, Theofilou D, Shibata T, Uchida S, Nakabayashi T and Kostopoulos GK. MEG tomography of human cortex and brainstem activity in waking and REM sleep saccades. Cerebral Cortex, 2004;14(1):56-72.
66. Sargsyan A, Melkonyan A, Mkrtchian H, Papatheodoropoulos C and Kostopoulos G. A computer model of field potential responses for the study of short-term plasticity in hippocampus . Journal of Neuroscience Methods 135 (2004) 175–191.
67. Tchekalarova J, Sotiriou E, Georgiev V, Kostopoulos G, Angelatou F. Up-regulation of adenosine A1 receptor binding in pentylenetetrazol kindling in mice: effects of angiotensin IV. Brain Res. 2005 Jan 25;1032(1-2):94-103.
68. Zainea O.F., Kostopoulos G.K., Ioannides A.A. Clustering of early cortical responses to median nerve stimulation from average and single trial MEG and EEG signals. Brain Topography 17 (4): 219-236, 2005
69. Papatheodoropoulos C, Moshovos C. and Kostopoulos GK , Greater contribution of NMDA receptors in ventral compared to dorsal hippocampal slices in the expression and long-term maintenance of epileptiform activity. Neuroscience, 2005, 135(3): 765-779.
70. Petrides T., Georgopoulos P, Kostopoulos G and Papatheodoropoulos C. "The GABA-A receptor-mediated recurrent inhibition in ventral compared with dorsal CA1 hippocampal region is weaker, decays faster and lasts shorter." Experimental Brain Research, 2007; 177 (3): 370-383 .
71. Moschovos C, Kostopoulos G, Papatheodoropoulos C. Long-term potentiation of high-frequency oscillation and synaptic transmission characterize in vitro NMDA receptor-dependent epileptogenesis in the hippocampus. Neurobiol Dis. 2008 Feb;29(2):368-80.
72. Koutras A, Kostopoulos GK and Ioannides AA 2008 Exploring the Variability of Single Trials in Somatosensory Evoked Responses Using Constrained Source Extraction and RMT. IEE. Transactions on Biomedical Engineering, vol. 55, no. 3, p. 957-969.
73. Ioannides A. and Kostopoulos GK 2008 Real-time tomography from magnetoencephalography (MEG)? Experimental and theoretical challenges, possible physiological basis and evidence from the analysis of real data. International Journal of Bioelectromagnetism Vol. 10, No. 1, pp. 37 – 51.
74. Georgopoulos P, Petrides T, Kostopoulos G and Papatheodoropoulos C; Varying magnitude of GABAergic recurrent inhibition enhancement by different sedative/anesthetic agents in dorsal and ventral hippocampus. Brain Res. 2008; 1207:43-59.
75. Kouvaras E, Asprodini EK, Asouchidou I, Vasilaki A, Kilindris T, Michaloudis D, Koukoutianou I, Papatheodoropoulos C, Kostopoulos G. Fentanyl treatment reduces GABAergic inhibition in the CA1 area of the hippocampus 24h after acute exposure to the drug. Neuropharmacology. 2008 Jul 26. [Epub ahead of print].
76. Ioannides A., Kostopoulos GK, Liu L., Fenwick PB, MEG Identifies Dorsal Medial Brain Activations during Sleep. Neuroimage, 2008 In Press.
- Laboratory for Human Brain Dynamics, AAI Scientific Cultural Services Ltd., Office 501, Galaxias Building Block A, 33 Arch. Makarios III Avenue, 1065 Nicosia, Cyprus. (Director: Dr. AA Ioannides
- Department of Clinical Neurophysiology and Epilepsies, St. Thomas' Hospital, Lambeth Wing, 3rd floor, London SE1 7EH, UK. Director: Dr. M. Koutroumanides.
- Laboratory of Pharmacology, School of Medicine, University of Thessaly, Faculty of Health Sciences, 22 Papakiriazi Street, 41222 Larissa, Greece. (Dr. E. Asprodini)
-
Additional Information
FP7 research themes for potential involvement:
“HEALTH” mainly through the actions “international cooperation” and “ideas / basic research”