Research Profile for Missirlis Yannis

General Research Group Record Title:

Biomechanics and Biomedical Engineering

Deparment(s):

Department of Mechanical and Aeronautical Engineering

Research Activity Research Field(s):

Nanosciences, nanotechnologies, materials & new production technologies
Health
Food, Agriculture and Fisheries, Biotechnology

Keywords:

biomaterials,single macromolecule(protein) adhesion mechanics,bacterial adhesion,biocompatibility,tissue engineering,regenerative medicine,surface biomechanics,cell-material interactions

Research activity:

current activities include: measurement of single macromolecule(protein) attachement forces using the AFM, bacterial adhesion and biofilm formation under dynamic flow conditions, endothelial cell responses to combined mechanical and flow environment in a bioreactor using various substrate biological matrices over tubular biomaterials, cell-protein-biomaterial interactions (experimental-theoretical), interfacial phenomena at bio-nonbio interfaces, nanomechanical investigations of biomaterials and tissues, biocompatibility aspects of novel biomaterials.

Research Infrastructure Name and position of staff members:

Yannis F.Missirlis, professor
Georgios P.A.Michanetzis, postdoctoral fellow
Maria Katsikogianni,postdoctoral fellow
Stergioa Dermenoudis,Ph.D. candidate

Facilities:

Confocal Laser Microscopy (3 lasers)
AFM
Fluoresence/optical/stereo microscopes
Nanoindentation apparatus
Three culture room facilities
Real-time PCR
Tensile equipments
Contact Angle
Micropipette aspiration facilities
Particle counter
ELISAs

Research Activities Selected research projects:

1. Bioreactive composite scaffold design (VASCUPLUG)- EU-FP6 2005-2008 NMP3-CT-2005-013811

2. Nanotechnology in Medicine (NANOMED)-Quality of life Program 2000-2003. QLK3-CT-2000-01500

3. BRITE-EURAM III-Contract CT98-0620.
"Development and Testing of Membranes for Biohybrid Systems" 1998-2001.
4. BRITE-EURAM III-Contract CT97-0415
"Development of Biomaterials with improved Resistance to infection" 1997-2000.

Selected publications:

56. G.P.A. Michanetzis, N. Katsala, Y.F. Missirlis, "Comparison of haemocompatibility improvement of four polymeric biomaterials by two heparinization techniques", Biomaterials 24, 677-688, 2003.

57. M. Katsikogianni and Y.F. Missirlis, “Concise review of mechanisms of bacterial adhesion to biomaterials and of techniques used in estimating bacteria-material interactions”, European Cells & Materials Journal,8, 37-57,2004.

58. Groth T, Seifert B, Albrecht W, Malsch G, Gross U, Fey-Lamprecht F, Michanetzis G, Missirlis Y, Engbers G., “Development of polymer membranes with improved haemocompatibility for biohybrid organ technology”,
Clin Hemorheol Microcirc. 2005;32(2):129-43.

59. Amanatides E., Mataras D., Katsikogianni M., Missirlis Y.F., “Plasma surface treatment of polyethylene terephtalate films for bacterial repellence“, Surface & Coatings Technology, ,200:6331-6335, 2006.

60. Koromila G., Michanetzis,G.P.A., Missirlis,Y.F. ,Antimisiaris,S.G., “Heparin incorporating liposomes as a delivery system of heparin from PET-covered metallic stents: Effect on haemocompatibility “, Biomaterials, 27, 2525-2533, 2006.

61. Katsikogianni M.,Spiliopoulou I., Dowling,D.P., Missirlis, Y.F., “ Adhesion of slime producing Staphylococcus epidermidis strains to PVC and diamond like carbon/silver/fluorinated coatings “, J Mater Sci: Mater Med 17, 679-689, 2006.

62. Antimisiaris,S.G., Koromila G., Michanetzis,G.P.A., Missirlis,Y.F., “Liposome Coated Stents: A Method to Deliver Drugs to the Site of Action and Improve Stent Blood-Compatibility”, Journal of Liposome Research, 16:303–309, 2006.

63. Katsikogianni M. G., Syndrevelis C. S., Amanatides E., Mataras D. S., Missirlis Y. F., “Plasma treated and a-C:H coated PET performance in inhibiting bacterial adhesion”, Plasma Processes and Polymers, 4( S1), : S1046-S1051 ,2007.
64. A. G. Moutzouri , A. T. Skoutelis , C.A. Gogos , Y. F. Missirlis , G. M. Athanassiou, “Red blood cell deformability in patients with sepsis: A marker for prognosis and monitoring of severity”, Clinical Hemorheology and Microcirculation, 36(4) : 291-299, 2007.
65. Th. S. Tsapikouni and Y.F.Missirlis, “pH and ionic strength effect on single fibrinogen molecule adsorption on mica studied with AFM”, Colloids and Surfaces B: Biointerfaces, 57, (1) : 89-96, 2007.
66. Y.F.Missirlis and M.Katsikogianni, “Theoretical and experimental approaches of bacteria-biomaterial interactions”, Mat.-wiss. U. Werkstofftech. 38(12),983-994, 2007.

67. Th.S.Tsapikouni, St. Allen, Y.F.Missirlis, “Measurement of interaction forces between fibrinogen coated probes and mica surface with the Atomic Force Microscope: The pH and ionic strength effect”, Biointerphases, 3(1),1-8 , 2008.
68. M. Katsikogianni, E. Amanatides, D. Mataras, Y.F. Missirlis. ‘Staphylococcus epidermidis adhesion to He, He/O2 plasma treated PET films and aged materials: Contributions of surface free energy and shear rate’, Colloids and Surfaces B: Biointerfaces, 65:257-268,2008
69. G.P.A.Michanetzis, Y.F.Missirlis and S.G.Antimisiaris, “ Haemocompatibility of Nanosized Drug Delivery Systems: Has it benn Adequately Considered?”, J.Biomed. Nanotechnol., 4(3) : 218-233,2008.

Cooperations with other Organizations and Institutes:

with several, mainly via the european projects

Additional Information Relevant email and URL addresses:

misirlis@mech.upatras.gr

Comments:

Research Profiles & Academic Directory

Contact Info

Research Development Office
Research Committee
University of Patras

Telephone:
+30 2610 996658

Fax:
+30 2610 996677

Email:
research_info@upatras.gr