Research Profile for Papachristou Dionysios

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Unit of Bone and Soft Tissue Studies
Laboratory of Anatomy-Histology-Embryology, University of Patras, School of Medicine, Patras, Greece
Research Activity
bone biology, bone/soft tissue pathology, obesity, obesity related bone diseases, molecular pathology
My research activity focuses on the following topics:
1. Molecular mechanisms implicated on the pathogenesis of bone and soft tissue sarcomas.
2. Pathobiology of metabolic bone diseases with emphasis to osteoporosis.
3. Pathobiology of osteoarthritis and other degenerative diseases.
4.Molecular mechanisms that are involved in the development of obesity-induced osteoarthritis and related pathologies
Research Infrastructure
1. Helen Papadakis MD, Associate Professor of Anatomy-Histology-Embryology, Univ. of Patras, School of Medicine, Patras, Greece
2. Eva-Irene Triantafyllidi, PhD
3. Ionanna Kotsikogianni PhD Student
4. Dimitris Panagiotopoulos PhD Student
5. Angeliki Korpetinou MSc

International collaborators:
1. George Michalopoulos MD, PhD, Professor of Pathology, Univ. of Pittsburgh, School of Medicine, Pittsburgh, PA, USA
2. Harry C. Blair MD, Professor of Pathology, Univ. of Pittsburgh, School of Medicine, Pittsburgh, PA, USA
3. Uma N.M. Rao MD, Professor of Pathology, Univ. of Pittsburgh, School of Medicine, Pittsburgh, PA, USA
4. Georgios I. Papachristou MD, Assistant Professor of Medicine, Univ. of Pittsburgh, School of Medicine, Pittsburgh, PA, USA
5. Alex Payatakes MD, Assistant Professor of Orthopedic Surgery, Penn State University, Hershey, PA, USA
6. Dr. Domenico Corradi, Assistant Professor of Pathology, Univ. of Parma, Italy
The Department of Medicine has all the equipment necessary for molecular-cell biology research. The Basic Sciences Division hosts most non-clinical researchers and occupies large laboratory spaces over three levels, with access to ample dedicated spaces for radioactivity, P2 contained functions, dark room, routine cell culture, PCR (Real-Time [Roche Lightcycler 2.0] and Standard), compound and confocal (Leica) imaging laboratory, phosphor-imager, Perkin-Elmer ScanArray microarray system (including HybArray 12 system), Agilent 2100 BioAnalyzer, computer room, library and seminar rooms, Olympus Electron Microscopy, adenovirus and an AAV facility.
Dr. Papachristou’s Lab is allocated approximately 150 m2 lab space equipped with benches and some basic laboratory equipment such as brightfield microscopes, microfuges, electrophoresis aparati and power supplies, dark room, cold room, precision micropipets, gas and vacuum lines, water lines, -80oC freezer and +4oC refrigerators. A separate fully-equipped cell culture facility for general culturing of cells is also available to me. Furthermore, the lab will have access to distilled/de-ionized water purifier, gas line, autoclave sterilizer, and ice. Electron microscopy, core facility providing DNA and protein related services such as DNA sequencing, microarray analysis and protein expression and purification is also available to the scientists of the University. In addition newly established state-of-the-art animal facility is also available. The facility operates under the provisions of an institutional animal and bioethics committee in accordance to the EU laws for the welfare of the animals. The University of Patras operates under the directives by the EU and the Greek law regarding handling of biohazard and radioactive materials. All experiments will be performed under the guidelines of the Protocol for the Protection and Welfare of the Animals, which are strictly enforced by the institutional animal committee of the University of Patras.
Research Activities
a) 2010-2014: Marie Curie Reintegration Grants (IRG), Call : FP7-PEOPLE-RG-2009, #256402-« apoeostearthritis » (100.000 Euros) code : D001

b) 2007-today: “Molecular, Immunohistochemical, Morphological analyses and Predictors of Local and Distant Recurrent and Outcome in Bone and Soft Tissue Sarcoma” IRB #: 0612060, University of Pittsburgh, Pittsburgh, PA, USA, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA

c) "Karathodori" Grant 2011-2014
Papachristou et al Histopathology 2011 (in press)
Karavia, Papachristou et al FEBS J 2011
Papachristou et al Virch Arciv 2011
Papachristou et al Med Res Rev 2010
Klironomos/Papachristou et al Brain Pathol 2010 20:490-7
Papachristou et al Cancer Genet Cytogenet 2009 191:46-50
Papachristou et al Bioessays 2009 31 794-804
Papachristou et al Eur J Cancer 2008 44:2518-25
Papachristou et al Mol Med 2008 14:160-6
Papachristou et al Histopathology 2007 51:499-508
Papadopoulou, Papachristou et al FEBS Lett 2007 581: 2041-6
Papachristou/Papachristou et al Am J Gastroenterol 2007 102:738-43
Papachristou and Papavassiliou Int J Biochem Cell Biol 2007 39:857-62
Papachristou, Papachristou et al Am J Gastroenterol 2006 101:2605-10
Papachristou et al Hum Pathol 2006 37:890-8
Papachristou, Papachristou et al Pancreatology 2006 6:279-85
Sun/Papachristou et al Cell 2006 125:247-60
Papachristou, Papachristou et al Histopathology 2005 47:565-74
Papachristou et al Bone 2003 32:364-71
1. University of Pittsburgh, School of Medicind, Pittsburgh, PA, USA (Dr. Harry Blair, Dr. Geogre Michalopoulos, Dr. Uma Rao, Dr. Georgios Papachristou, Dr. Carry Wu)
2. Mayo Clinic, Rochester, MN, USA (Dr. Carry Inwards)
3. Penn State Hershey Bone and Joint Institute, PA, USA (Dr. Alexander Payatakes)
4. Univ. of Parma. Italy (Dr. Domenico Corradi)
5. University of Athens, School of Medicine, Athens. Greece (Dr. Athanassios G. Papavassilou)
6. Univ. of Patras, School of Medicine, Patras, Greece (Dr. Haralabos Kalofonos MD, Dr. Kyriakos Kypreos)
6. University of Larissa, Larissa, Greece (Dr. Vassilios Kontogeorgakos, Orthopedic Surgeon)
Additional Information
Dr. Papachristou MD, PhD is a specialized bone and soft tissue pathologist who has been trained at the Department of Pathology at the University of Pittsburgh, School of Medicine, Pittsburgh, PA, where he served as full faculty member. He has also been trained at the Department of Pathology and Laboratory Medicine at Mayo Clinic, Rochester, MN, USA. Currently Dr. Papachristou is an Assistant Professor at the University of Patras, School of Medicine, Patras, Greece and an Assistant Professor (Adj.) at the Dept. of Pathology, University of Pittsburgh, PA, USA. He has 40 publications at high-impact, peer-reviewed journals.